STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation.

  title={STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation.},
  author={Maria Vittoria Verga Falzacappa and Maja Vuji{\'c} Spasi{\'c} and Regina Kessler and Jens Stolte and Matthias W. Hentze and Martina U. Muckenthaler},
  volume={109 1},
Hepcidin is a key iron-regulatory hormone produced by the liver. Inappropriately low hepcidin levels cause iron overload, while increased hepcidin expression plays an important role in the anemia of inflammation (AI) by restricting intestinal iron absorption and macrophage iron release. Its expression is modulated in response to body iron stores, hypoxia, and inflammatory and infectious stimuli involving at least in part cytokines secreted by macrophages. In this study we established and… CONTINUE READING
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Hepcidin and regulation of body iron metabolism

  • T Ganz, IV NemethE.Ironimports.
  • Am J Physiol Gastrointest Liver Physiol
  • 2006

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