STAT3 mediates IL-6-induced growth inhibition in the human prostate cancer cell line LNCaP.

@article{Spiotto2000STAT3MI,
  title={STAT3 mediates IL-6-induced growth inhibition in the human prostate cancer cell line LNCaP.},
  author={Michael T Spiotto and Theodore D.K. Chung},
  journal={The Prostate},
  year={2000},
  volume={42 2},
  pages={
          88-98
        }
}
BACKGROUND In prostate cancer, we and others have observed distinct phenotypic responses to interleukin-6 (IL-6), which acts either as a paracrine growth inhibitor in the LNCaP cell line or as an autocrine growth stimulator in PC-3, DU145, and TSU cell lines. To understand the underlying mechanism responsible for this phenotypic difference, we investigated differences in the IL-6-induced Janus kinase-signal transducers and activators of transcription (JAK-STAT) signal transduction pathway… CONTINUE READING

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