STAT3 mediates C6-ceramide-induced cell death in chronic lymphocytic leukemia

@inproceedings{Doshi2017STAT3MC,
  title={STAT3 mediates C6-ceramide-induced cell death in chronic lymphocytic leukemia},
  author={Ushma A. Doshi and Jeremy Shaw and Todd E. Fox and David F. Claxton and Thomas P. Loughran and Mark Kester},
  booktitle={Signal Transduction and Targeted Therapy},
  year={2017}
}
The pathogenesis of chronic lymphocytic leukemia (CLL) is poorly understood and it remains incurable with current therapies. We have previously shown that nanoliposomal C6-ceramide (CNL) is an effective therapy in an in vivo murine model of CLL. However, the key signaling pathways mediating CNL-induced cell death in CLL remains unknown. We hypothesized that CNL targets STAT3, a critical regulator of hematopoietic biology. We observed that CNL treatment reduced phosphorylated STAT3 at both Y705… CONTINUE READING
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