STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF.

@article{Pechkovsky2012STAT3mediatedSD,
  title={STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF.},
  author={Dmitri V. Pechkovsky and Cecilia M. Pr{\^e}le and John Wong and Cory M Hogaboam and Robin J McAnulty and Geoffrey J. Laurent and Samuel S-M Zhang and Mois{\'e}s Selman and Steven E Mutsaers and Darryl A Knight},
  journal={The American journal of pathology},
  year={2012},
  volume={180 4},
  pages={
          1398-412
        }
}
STAT3 is a latent transcription factor that plays a role in regulating fibroblast function in fibrotic lung diseases. To further understand the role of STAT3 in the phenotypic divergence and function of human lung fibroblasts (LFs), we investigated the effect of basal and cytokine-induced STAT3 activity on indices of LF differentiation and activation, including expression of α-smooth muscle actin (α-SMA), collagen, and adhesion molecules Thy-1/CD90 and α(v) β(3) and β(5) integrins. We… CONTINUE READING

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