STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production.

@article{Owaki2008STAT3II,
  title={STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production.},
  author={Toshiyuki Owaki and Masayuki Asakawa and Noriko Morishima and Izuru Mizoguchi and Fumio Fukai and Kiyoshi Takeda and Junichiro Mizuguchi and Takayuki Yoshimoto},
  journal={Journal of immunology},
  year={2008},
  volume={180 5},
  pages={2903-11}
}
IL-27, a member of the IL-6/IL-12 family, activates both STAT1 and STAT3 through its receptor, which consists of WSX-1 and gp130 subunits, resulting in augmentation of Th1 differentiation and suppression of proinflammatory cytokine production. In the present study, we investigated the role of STAT3 in the IL-27-mediated immune functions. IL-27 induced phosphorylation of STAT1, -2, -3 and -5 in wild-type naive CD4+ T cells, but failed to induce that of STAT3 and STAT5 in STAT3-deficient cohorts… CONTINUE READING

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