STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis

@article{Holtick2005STAT3IE,
  title={STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis},
  author={Udo Holtick and Martina Vockerodt and Diana Pinkert and Nils Schoof and Benjamin St{\"u}rzenhofecker and N Kussebi and Kirsten Lauber and Sebastian Wesselborg and Dennis Loeffler and Felicitas Horn and Lorenz H. Tr{\"u}mper and Dieter Kube},
  journal={Leukemia},
  year={2005},
  volume={19},
  pages={936-944}
}
Classical Hodgkin lymphoma (cHL) is a distinct malignancy of the immune system. Despite the progress made in the understanding of the biology of cHL, the transforming events remain to be elucidated. Recently, we demonstrated that the Janus kinase inhibitor AG490 blocked cellular proliferation and STAT3 phosphorylation in cHL. To explore the potential of constitutively activated STAT3 as a drug target and its role in cHL pathogenesis, different cHL cell lines were analyzed. Treatment of cHL… CONTINUE READING
41 Citations
45 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 45 references

Similar Papers

Loading similar papers…