STAT3 integrates cytokine and neurotrophin signals to promote sympathetic axon regeneration.

Abstract

The transcription factor STAT3 has been implicated in axon regeneration. Here we investigate a role for STAT3 in sympathetic nerve sprouting after myocardial infarction (MI) - a common injury in humans. We show that NGF stimulates serine phosphorylation (S727) of STAT3 in sympathetic neurons via ERK1/2, in contrast to cytokine phosphorylation of Y705… (More)
DOI: 10.1016/j.mcn.2013.06.005

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.