STAT3 as a therapeutic target in head and neck cancer

@article{Leeman2006STAT3AA,
  title={STAT3 as a therapeutic target in head and neck cancer},
  author={R. Leeman and V. W. Lui and J. Grandis},
  journal={Expert Opinion on Biological Therapy},
  year={2006},
  volume={6},
  pages={231 - 241}
}
The signal transducer and activator of transcription (STAT) proteins relay signals from cytokine receptors and receptor tyrosine kinases on the cell surface to the nucleus, where they affect the transcription of genes involved in normal cell functions, including growth, apoptosis and differentiation. STAT3 has been found to be constitutively active in head and neck squamous cell carcinoma (HNSCC) as well as in other epithelial malignancies. In HNSCC, STAT3 alters the cell cycle, prevents… Expand
Review of STAT3 (Signal Transducers and Activators of Transcription) in head and neck cancer.
  • S. Mali
  • Medicine, Biology
  • Oral oncology
  • 2015
Jak/STAT Signaling in HNC
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