STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo.

@article{Kijima2002STAT3AA,
  title={STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo.},
  author={Taro Kijima and Hideo Niwa and Richard A. Steinman and Stephanie D. Drenning and W. E. Gooding and Abbey Lynn Wentzel and Sichuan Xi and Jennifer R Grandis},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={2002},
  volume={13 8},
  pages={355-62}
}
Epidermal growth factor receptor (EGFR) is up-regulated and contributes to the loss of growth control in squamous cell carcinoma of the head and neck (SCCHN). Previously, we reported an association between autocrine stimulation of EGFR and constitutive signal transducers and activators of transcription (STAT) 3 activation in SCCHN cells in vitro and in vivo. Here, we evaluated the role of activated STAT3 in tumor progression and EGFR-independent mitogenic signaling. We found that SCCHN cells… CONTINUE READING