STAT3: a multifaceted oncogene.

  title={STAT3: a multifaceted oncogene.},
  author={David E Levy and Giorgio Inghirami},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 27},
  • David E Levy, Giorgio Inghirami
  • Published 2006 in
    Proceedings of the National Academy of Sciences…
  • DOI:10.1073/pnas.0604042103
S ignal transducers and activators of transcription (STAT) proteins are a family of transcription factors first characterized for their role in cytokine signaling. These versatile proteins contain a site for specific tyrosine phosphorylation, a modification that results in a conformational rearrangement and dimerization through phosphotyrosine–SH2 domain interactions (1). Once activated in this manner, phosphorylated STAT protein dimers accumulate in the cell nucleus, bound to enhancer elements… CONTINUE READING


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