STAT3: An Anti-Invasive Factor in Colorectal Cancer?

@inproceedings{Jong2014STAT3AA,
  title={STAT3: An Anti-Invasive Factor in Colorectal Cancer?},
  author={Petrus Rudolf de Jong and Ji-Hun Mo and Alexandra R. Harris and Jongseok Lee and Eyal Raz},
  booktitle={Cancers},
  year={2014}
}
Signal Transducer and Activator of Transcription 3 (STAT3) is activated in a majority of cancers, and promotes tumorigenesis and even metastasis through transcriptional activation of its target genes. Recently, we discovered that STAT3 suppresses epithelial-to-mesenchymal transition (EMT) and thus metastasis in a mouse model of colorectal cancer (CRC), while it did not affect the overall tumor burden. Furthermore, we found that STAT3 in intestinal epithelial cells (IEC) suppresses EMT by… CONTINUE READING

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