STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α

@inproceedings{Yamauchi2016STAT1IE,
  title={STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α},
  author={Shota Yamauchi and Kenji Takeuchi and Kazuyasu Chihara and Chisato Honjoh and Yuji Kato and Hatsumi Yoshiki and Hak Hotta and Kiyonao Sada},
  booktitle={Scientific reports},
  year={2016}
}
Interferon-α (IFN-α) and IFN-λ are structurally distinct cytokines that bind to different receptors, but induce expression of similar sets of genes through Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathways. The difference between IFN-α and IFN-λ signaling remains poorly understood. Here, using the CRISPR/Cas9 system, we examine the role of STAT1 and STAT2 in the inhibition of hepatitis C virus (HCV) replication by IFN-α and IFN-λ. Treatment with IFN… CONTINUE READING
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