STAT1 expression in dendritic cells, but not T cells, is required for immunity to Leishmania major.

@article{Johnson2007STAT1EI,
  title={STAT1 expression in dendritic cells, but not T cells, is required for immunity to Leishmania major.},
  author={Leanne M. Johnson and Phillip Scott},
  journal={Journal of immunology},
  year={2007},
  volume={178 11},
  pages={7259-66}
}
The generation of Th1 responses is important for resistance to intracellular pathogens, including the parasite, Leishmania major. Although IFN-gammaR/STAT1 signaling promotes a Th1 response via the up-regulation of T-bet, the requirement for STAT1 in Th1 cell differentiation remains controversial. Although in some cases Th1 cells develop independently of STAT1, STAT1(-/-) mice fail to develop a Th1 response during L. major infection. However, the interpretation of this result is complicated by… CONTINUE READING