STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas

@inproceedings{Chan2011STAT1deficientMS,
  title={STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas},
  author={Szeman Ruby Chan and William Vermi and Jingqin Luo and Laura Lucini and Charles G. Rickert and Amy M. Fowler and Silvia Lonardi and Cora D. Arthur and Larry JT Young and David E. Levy and Michael J. Welch and Robert Cardiff and Robert D Schreiber},
  booktitle={Breast Cancer Research},
  year={2011}
}
Although breast cancers expressing estrogen receptor-α (ERα) and progesterone receptors (PR) are the most common form of mammary malignancy in humans, it has been difficult to develop a suitable mouse model showing similar steroid hormone responsiveness. STAT transcription factors play critical roles in mammary gland tumorigenesis, but the precise role of STAT1 remains unclear. Herein, we show that a subset of human breast cancers display reduced STAT1 expression and that mice lacking STAT1… CONTINUE READING
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