STAT1/IRF-1 signaling pathway mediates the injurious effect of interferon-gamma on oligodendrocyte progenitor cells.

@article{Wang2010STAT1IRF1SP,
  title={STAT1/IRF-1 signaling pathway mediates the injurious effect of interferon-gamma on oligodendrocyte progenitor cells.},
  author={Yanli Wang and Zhihua Ren and Duan Tao and Shilpa Tilwalli and Rajendra Goswami and Roumen Balabanov},
  journal={Glia},
  year={2010},
  volume={58 2},
  pages={195-208}
}
Interferon-gamma (IFN-gamma) is a pleiotropic cytokine that is critically involved in the pathogenesis of inflammatory demyelinating diseases. There is strong evidence that IFN-gamma can function as a distinct and independent injurious factor to oligodendrocyte progenitor cells (OPCs). The intracellular signaling pathways leading to OPC death, however, remain poorly understood. In this study, we examined IFN-gamma signaling in OPCs in relation to cell death in vitro. Using expression knock-down… CONTINUE READING

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Interferon - gamma ( IFN - gamma ) is a pleiotropic cytokine that is critically involved in the pathogenesis of inflammatory demyelinating diseases .
Interferon - gamma ( IFN - gamma ) is a pleiotropic cytokine that is critically involved in the pathogenesis of inflammatory demyelinating diseases .
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