STAT Is an Essential Activator of the Zygotic Genome in the Early Drosophila Embryo

  title={STAT Is an Essential Activator of the Zygotic Genome in the Early
                        Drosophila Embryo},
  author={Amy Tsurumi and Fan Xia and Jinghong Li and Kimberly R Larson and Russell M Lafrance and Willis X. Li},
  booktitle={PLoS genetics},
In many organisms, transcription of the zygotic genome begins during the maternal-to-zygotic transition (MZT), which is characterized by a dramatic increase in global transcriptional activities and coincides with embryonic stem cell differentiation. In Drosophila, it has been shown that maternal morphogen gradients and ubiquitously distributed general transcription factors may cooperate to upregulate zygotic genes that are essential for pattern formation in the early embryo. Here, we show that… CONTINUE READING

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