STAT-6 is an absolute requirement for murine rejection of Hymenolepis diminuta.

@article{McKay2003STAT6IA,
  title={STAT-6 is an absolute requirement for murine rejection of Hymenolepis diminuta.},
  author={D M McKay and Wallul I Khan},
  journal={The Journal of parasitology},
  year={2003},
  volume={89 1},
  pages={188-9}
}
Infection with helminth parasites typically evokes a T helper 2-cell response in the mammalian host. Interleukin (IL)-4 and IL-13 are important in the rapid expulsion of parasitic nematodes, with the absence of either cytokine being compensated for by the other. However, the IL-4 and IL-13 common signaling molecule, signal transducer and activator of transcription 6 (STAT-6) appears to be mandatory for the spontaneous expulsion of enteric helminths. Mice genetically deficient in IL-4, IL-13, or… CONTINUE READING