STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease.

@article{Lu2008STAT3AE,
  title={STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease.},
  author={Sydney X. Lu and Onder S Alpdogan and Janine T. Lin and Robert Balderas and Roberto Campos-Gonz{\'a}lez and Xiao Wang and Guo-Jian Gao and David B Suh and Christopher King and Melanie Chow and O. Makai Smith and Vanessa M. Hubbard and Johanne L. Bautista and Javier Cabrera-Perez and Johannes L. Zakrzewski and Adam A. Kochman and Andrew Z Chow and Gr{\'e}goire Altan-Bonnet and Marcel R M van den Brink},
  journal={Blood},
  year={2008},
  volume={112 13},
  pages={
          5254-8
        }
}
Graft-versus-host disease (GVHD) is a serious complication of allogeneic bone marrow transplantation, and donor T cells are indispensable for GVHD. Current therapies have limited efficacy, selectivity, and high toxicities. We used a novel flow cytometry technique for the analysis of intracellular phosphorylation events in single cells in murine BMT models to identify and validate novel GVHD drug targets.(1-7) This method circumvents the requirement for large numbers of purified cells, unlike… CONTINUE READING
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