STAMP2 is required for human adipose-derived stem cell differentiation and adipocyte-facilitated prostate cancer growth in vivo

@inproceedings{Lindstad2017STAMP2IR,
  title={STAMP2 is required for human adipose-derived stem cell differentiation and adipocyte-facilitated prostate cancer growth in vivo},
  author={Torstein Lindstad and Su Rong Qu and J{\o}rgen Sikkeland and Yang Jin and Alexandr Kristian and Gunhild Mari M{\ae}landsmo and Philippe Collas and Fahri Saatcioglu},
  booktitle={Oncotarget},
  year={2017}
}
Six Transmembrane Protein of Prostate 2 (STAMP2) has been implicated in both prostate cancer (PCa) and metabolic disease. STAMP2 has unique anti-inflammatory and pro-metabolic properties in mouse adipose tissue, but there is limited information on its role in human metabolic tissues. Using human adipose-derived stem cells (ASCs), we report that STAMP2 expression is dramatically upregulated during adipogenesis. shRNA-mediated STAMP2 knockdown in ASCs significantly suppresses adipogenesis and… CONTINUE READING

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