STAM-AMSH interaction facilitates the deubiquitination activity in the C-terminal AMSH.

@article{Kim2006STAMAMSHIF,
  title={STAM-AMSH interaction facilitates the deubiquitination activity in the C-terminal AMSH.},
  author={Man Su Kim and Jeom-A Kim and Hyun Kyu Song and Hyesung Jeon},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={351 3},
  pages={612-8}
}
Signal transducing adaptor molecule (STAM) complexed with hepatocyte growth factor regulated tyrosine kinase substrate (Hrs) works on sorting of cargo proteins in multivesicular body (MVB) pathway. Associated molecule with SH3 domain of STAM (AMSH), a zinc-containing ubiquitin isopeptidase, is thought to play a role in regulation of ubiquitin-mediated degradation by binding to STAM. We have found that AMSH requires the conformation of Px(V/I)(D/N)RxxKP sequence to bind SH3 domain of STAM with… CONTINUE READING

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