ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes.

Abstract

The precise glycosyltransferase enzymes that mediate selectin-ligand biosynthesis in human leukocytes are unknown. This knowledge is important because selectin-mediated cell tethering and rolling is a critical component of both normal immune response and various vascular disorders. We evaluated the role of 3 α(2,3)sialyltransferases, ST3Gal-3, -4, and -6… (More)
DOI: 10.1182/blood-2014-07-588590

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@article{Mondal2015ST3Gal4IT, title={ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes.}, author={Nandini Mondal and Alexander Buffone and Gino Stolfa and Aristotelis Antonopoulos and Joseph T. Y. Lau and Stuart M. Haslam and Anne Dell and Sriram Neelamegham}, journal={Blood}, year={2015}, volume={125 4}, pages={687-96} }