ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance

@article{Brint2004ST2IA,
  title={ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance},
  author={Elizabeth K. Brint and D -M. Xu and Haiying Liu and Aisling Dunne and Andrew N. J. McKenzie and Luke A J O'Neill and Foo Yew Eddy Liew},
  journal={Nature Immunology},
  year={2004},
  volume={5},
  pages={373-379}
}
The Toll–interleukin 1 receptor (TIR) superfamily, defined by the presence of an intracellular TIR domain, initiates innate immunity through activation of the transcription factor NF-κB, leading to the production of proinflammatory cytokines. ST2 is a member of the TIR family that does not activate NF-κB and has been suggested as an important effector molecule of T helper type 2 (TH2) responses. We show here that the membrane-bound form of ST2 negatively regulated type I interleukin 1 receptor… CONTINUE READING
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