SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier

  title={SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier},
  author={Seo-Yeon Lee and Woo Jean Kim and Yoon Kyung Choi and Hyun Seok Song and Myung Jin Son and Irwin H. Gelman and Y Kim and Kyu-Won Kim},
  journal={Nature Medicine},
The blood-brain barrier (BBB) is essential for maintaining brain homeostasis and low permeability. BBB maintenance is important in the central nervous system (CNS) because disruption of the BBB may contribute to many brain disorders, including Alzheimer disease and ischemic stroke. The molecular mechanisms of BBB development remain ill-defined, however. Here we report that src-suppressed C-kinase substrate (SSeCKS) decreases the expression of vascular endothelial growth factor (VEGF) through AP… CONTINUE READING
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