SSX2IP expression in acute myeloid leukaemia: an association with mitotic spindle failure in t(8;21), and cell cycle in t(15;17) patients.

@article{Guinn2007SSX2IPEI,
  title={SSX2IP expression in acute myeloid leukaemia: an association with mitotic spindle failure in t(8;21), and cell cycle in t(15;17) patients.},
  author={Barbara-Ann Guinn and Lars Bullinger and N. S. Thomas and Kenneth Ian Mills and Jochen Greiner},
  journal={British journal of haematology},
  year={2007},
  volume={140 2},
  pages={
          250-1
        }
}
We show that SSX2IP is affected in two ways which relate to the cell cycling of AML cells. In patients harbouring the t(15;17) translocation overexpression of SSX2IP is associated with an abnormal elevation in the expression of genes involved in cell cycle. Conversely in AML cells harbouring the t(8;21) translocation, the low levels of SSX2IP are associated with low levels of CDC20 protein, part of the anaphase-promoting complex which is thought to contribute to the development of aneuploidy… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Antigenic Targets for the Immunotherapy of Acute Myeloid Leukaemia

  • Journal of clinical medicine
  • 2019
VIEW 6 EXCERPTS
CITES BACKGROUND & RESULTS