SSRIs and Ejaculation: A Double-Blind, Randomized, Fixed-Dose Study With Paroxetine and Citalopram

@article{Waldinger2001SSRIsAE,
  title={SSRIs and Ejaculation: A Double-Blind, Randomized, Fixed-Dose Study With Paroxetine and Citalopram},
  author={Marcel D. Waldinger and Aeilko H. Zwinderman and Berend Olivier},
  journal={Journal of Clinical Psychopharmacology},
  year={2001},
  volume={21},
  pages={556-560}
}
Selective serotonin reuptake inhibitors (SSRIs) are known to induce delayed orgasm and ejaculation. However, different SSRIs may differentially delay ejaculation. A double-blind, fixed-dose study in healthy men with lifelong rapid ejaculation was performed to evaluate potential differences between clinically relevant doses of two selective serotonin reuptake inhibitors, paroxetine and citalopram, in their effects on ejaculation. Thirty men with an intravaginal ejaculation latency time (IELT… 
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102 Citations

Antidepressants and Ejaculation: A Double-Blind, Randomized, Fixed-Dose Study With Mirtazapine and Paroxetine
TLDR
Earlier findings that paroxetine, but not mirtazapine, significantly delays orgasm and ejaculation in men with early ejaculation are confirmed, whereas mirtzapine is devoid of any effect on it are confirmed.
Safety and efficacy of citalopram in the treatment of premature ejaculation: a double-blind placebo-controlled, fixed dose, randomized study
TLDR
It is indicated that citalopram has significantly better results in terms of IVELT and intercourse satisfaction versus placebo and to prolong the efficacy of this drug in PE.
On-demand treatment of premature ejaculation with clomipramine and paroxetine: a randomized, double-blind fixed-dose study with stopwatch assessment.
Safety and efficacy of escitalopram in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study
TLDR
Treatment of patients with definite PE with a daily dose of escitalopram 10 mg/day resulted in a delay in ejaculation measured by IELT, and side effects of the drug that arose during therapy decreased gradually to become insignificant at 4 weeks of treatment.
Safety and Efficacy of Tramadol in the Treatment of Premature Ejaculation: A Double-blind, Placebo-Controlled, Fixed-Dose, Randomized Study
TLDR
Tramadol seems to provide significantly better results in terms of intravaginal ejaculatory latency time and intercourse satisfaction versus placebo, and further studies are required to draw final conclusions on the efficacy of this drug in premature ejaculation.
Safety and Efficacy of Escitalopram in the Treatment of Premature Ejaculation: A Double-Blind, Placebo-Controlled, Fixed-Dose, Randomized Study
  • M. Safarinejad
  • Medicine, Psychology
    Journal of clinical psychopharmacology
  • 2007
TLDR
Oral escitalopram is an effective treatment for PE with long-term benefit for the patient after it is withdrawn, and further studies are required to draw final conclusions on the efficacy of this drug in PE.
Comparison Between Tadalafil Plus Paroxetine and Paroxetine Alone in the Treatment of Premature Ejaculation
TLDR
The results of the study show that tadalafil can increase the mean IELT and can be used for treatment of premature ejaculation in combination with paroxetine.
The effects of citalopram and fluoxetine on sexual behavior in healthy men: evidence of delayed ejaculation and unaffected sexual desire. A randomized, placebo-controlled, double-blind, double-dummy, parallel group study.
TLDR
Citalopram and fluoxetine did not directly affect penile erection as objectively assessed by RigiScan, although an impairment in the subjective assessment of erectile function was observed, and it was thought to be a possible consequence of the delayed ejaculation perceived as a trouble.
On-demand SSRI treatment of premature ejaculation: pharmacodynamic limitations for relevant ejaculation delay and consequent solutions.
TLDR
On-demand SSRIs with short half-life that insufficiently delay ejaculation in men with IELTs less than 1 minute should be called ejaculation-delaying drugs rather than drugs against premature ejaculation.
Treatment of premature ejaculation in the Asia-Pacific region: results from a phase III double-blind, parallel-group study of dapoxetine.
TLDR
Dapoxetine treatment significantly prolonged IELT and improved PEP measures and was generally well tolerated in men with PE in the Asia-Pacific region.
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