SSRIs and Ejaculation: A Double-Blind, Randomized, Fixed-Dose Study With Paroxetine and Citalopram
@article{Waldinger2001SSRIsAE, title={SSRIs and Ejaculation: A Double-Blind, Randomized, Fixed-Dose Study With Paroxetine and Citalopram}, author={Marcel D. Waldinger and Aeilko H. Zwinderman and Berend Olivier}, journal={Journal of Clinical Psychopharmacology}, year={2001}, volume={21}, pages={556-560} }
Selective serotonin reuptake inhibitors (SSRIs) are known to induce delayed orgasm and ejaculation. However, different SSRIs may differentially delay ejaculation. A double-blind, fixed-dose study in healthy men with lifelong rapid ejaculation was performed to evaluate potential differences between clinically relevant doses of two selective serotonin reuptake inhibitors, paroxetine and citalopram, in their effects on ejaculation. Thirty men with an intravaginal ejaculation latency time (IELT…
102 Citations
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Earlier findings that paroxetine, but not mirtazapine, significantly delays orgasm and ejaculation in men with early ejaculation are confirmed, whereas mirtzapine is devoid of any effect on it are confirmed.
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- Medicine
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Tramadol seems to provide significantly better results in terms of intravaginal ejaculatory latency time and intercourse satisfaction versus placebo, and further studies are required to draw final conclusions on the efficacy of this drug in premature ejaculation.
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- 2007
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- MedicineNephro-urology monthly
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The results of the study show that tadalafil can increase the mean IELT and can be used for treatment of premature ejaculation in combination with paroxetine.
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- 2008
Citalopram and fluoxetine did not directly affect penile erection as objectively assessed by RigiScan, although an impairment in the subjective assessment of erectile function was observed, and it was thought to be a possible consequence of the delayed ejaculation perceived as a trouble.
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On-demand SSRIs with short half-life that insufficiently delay ejaculation in men with IELTs less than 1 minute should be called ejaculation-delaying drugs rather than drugs against premature ejaculation.
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Dapoxetine treatment significantly prolonged IELT and improved PEP measures and was generally well tolerated in men with PE in the Asia-Pacific region.
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