SSRI Treatment suppresses dream recall frequency but increases subjective dream intensity in normal subjects

  title={SSRI Treatment suppresses dream recall frequency but increases subjective dream intensity in normal subjects},
  author={Edward F Pace-Schott and Tamara Gersh and Rosalia Silvestri and Robert Stickgold and Carl Salzman and J. Allan Hobson},
  journal={Journal of Sleep Research},
Clinical lore and a small number of published studies report that the selective serotonin reuptake inhibitors (SSRIs) intensify dreaming. This study examines the dream effects of paroxetine and fluvoxamine in order to both increase clinical knowledge of these agents and to test an important potential method for probing the relationship between REM sleep neurobiology and dreaming in humans. Fourteen normal, paid volunteers (4 males, 10 females; mean age 27.4 year, range 22–39) free of medical or… 
Serotonin and dreaming
Many clinical anecdotes and an experimental study have reported intensification of dreaming by the selective serotonin-reuptake inhibitors (SSRIs). However, no published neurochemical dream model
Changes in dream experience in relation with antidepressant escitalopram treatment in depressed female patients: a preliminary study.
The results of the present study evidence how the changes in some specific dreaming characteristics, such as the subjective recall of dream activity, the dreaming recall quality, the dream emotional content and the dream complexity represent reliable markers of the effectiveness of antidepressant therapy.
Dreams, Sleep, and Psychotropic Drugs
The reduction of intra-sleep awakenings seems to be the parameter explaining best the modulation of DRF by psychotropic drugs, which is coherent with the “arousal-retrieval model” stating that nighttime awakenings enable dreams to be encoded into long-term memory and therefore facilitate dream recall.
Drug Effects on Dreaming
This chapter discusses the effects of medications on dreaming, and reviews the literature on drugs and dreaming or dream content even if it is well-known that many antidepressant drugs may cause nightmares or frightening dreams.
Sertraline and rapid eye movement sleep without atonia: An 8-week, open-label study of depressed patients
  • Bin Zhang, Y. Hao, I. Arnulf
  • Psychology, Medicine
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2013
Dreaming without REM sleep
Nightmares and bad dreams in patients with borderline personality disorder: Fantasy as a coping skill?
ABSTRACT – Background and Objectives: Previous studies reported a high prevalence of nightmares and dream anxiety in Borderline Personality Disorder (BPD) and the severity of dream disturbances


Investigations of morning and laboratory dream recall and content in depressive patients during baseline conditions and under antidepressive treatment with trimipramine.
Morning as well as laboratory dream recall in depressive inpatients was drastically reduced and antidepressive treatment with trimipramine led to a positive influence on patients' mood that was paralleled by a change of dream mood in a positive direction.
Effects of fluvoxamine and paroxetine on sleep structure in normal subjects: a home-based Nightcap evaluation during drug administration and withdrawal.
The laboratory polysomnographic findings of SSRI-induced sleep quality changes are confirmed and the Nightcap's efficacy as an inexpensive longitudinal monitor for objective sleep changes induced by psychotropic medication is demonstrated.
Sleep laboratory studies on the single-dose effects of serotonin reuptake inhibitors paroxetine and fluoxetine on human sleep and awakening qualities.
Sleep quality, attention, concentration and reaction performance improved under paroxetine as compared to baseline, and the deterioration of well-being under PX 40 might be related to the appearance of drowsiness and nausea.
REM sleep enhancement by bupropion in depressed men.
This study represents the first report of an antidepressant medication that shortens REM latency and increases REM sleep and may require a revision of the current understanding of the relation among depression, REM sleep, and anti-depressant mechanisms.
Effects of Fluoxetine on the Polysomnogram in Outpatients with Major Depression
Medication and Dreams: Changes in Dream Content After Drug Treatment
This case study examines the effects of sertraline (ZoloftTM) on the dream content of a young woman with generalized anxiety disorder and panic attacks. The study used the major categories of Hall
Citalopram in the treatment of obsessive‐compulsive disorder: an open pilot study
The results suggest that citalopram may be effective in the treatment of obsessive‐compulsive disorder.
The cholinergic rapid eye movement sleep induction test with RS-86. State or trait marker of depression?
The application of this compound before sleep led to a significantly faster induction of REM sleep at the beginning of the night in patients with major depressive disorders compared with healthy subjects and patients with other nondepressive psychiatric diseases, such as eating disorders.
Serotonin reuptake inhibitor withdrawal.
Reports of withdrawal symptoms in a retrospective chart review of 352 patients treated in an outpatient clinic with the nonselective serotonin reuptake inhibitor clomipramine or with one of the selective SSRIs, fluoxetine, fluvoxamine, paroxettine, or sertraline suggest a role has been suggested for serotonin in coordinating sensory and autonomic function with motor activity.
Intrinsic dreams are not produced without REM sleep mechanisms: evidence through elicitation of sleep onset REM periods
Although ‘dreaming’ may occur during both REM and NREM periods as previous researchers have suggested, the dreams obtained from these distinct periods differ significantly in their quantitative and qualitative aspects and are likely to be produced by different mechanisms.