SSR240600 [(R)-2-(1-{2-[4-{2-[3,5-Bis(trifluoromethyl)phenyl]acetyl}-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl}-4-piperidinyl)-2-methylpropanamide], a Centrally Active Nonpeptide Antagonist of the Tachykinin Neurokinin 1 Receptor: II. Neurochemical and Behavioral Characterization

@article{Steinberg2002SSR240600A,
  title={SSR240600 [(R)-2-(1-\{2-[4-\{2-[3,5-Bis(trifluoromethyl)phenyl]acetyl\}-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl\}-4-piperidinyl)-2-methylpropanamide], a Centrally Active Nonpeptide Antagonist of the Tachykinin Neurokinin 1 Receptor: II. Neurochemical and Behavioral Characterization},
  author={R. Steinberg and R. Alonso and L. Rouquier and C. Desvignes and J. Michaud and A. Cudennec and Mireille Jung and J. Simiand and G. Griebel and X. Emonds‐Alt and G. Le Fur and P. Soubrié},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2002},
  volume={303},
  pages={1180 - 1188}
}
SSR240600 [(R)-2-(1-{2-[4-{2-[3,5-bis(trifluoromethyl)phenyl]acetyl}-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl}-4-piperidinyl)-2-methylpropanamide], a new nonpeptide tachykinin neurokinin 1 (NK1) receptor antagonist, was evaluated against the neurochemical, electrophysiological, and behavioral effects provoked by direct activation of brain tachykinin NK1 receptors or by stress in guinea pigs. SSR240600 (0.1–10 mg/kg i.p. or p.o.) antagonized the excitatory effect of i.c.v. infusion of [Sar9… Expand
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