SSO1450 – A CAS1 protein from Sulfolobus solfataricus P2 with high affinity for RNA and DNA

@article{Han2009SSO1450A,
  title={SSO1450 – A CAS1 protein from Sulfolobus solfataricus P2 with high affinity for RNA and DNA},
  author={Dong Han and Kathleen C. Lehmann and G. Krauss},
  journal={FEBS Letters},
  year={2009},
  volume={583}
}
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CRISPR-mediated defense mechanisms in the hyperthermophilic archaeal genus Sulfolobus
TLDR
Recent progress made in understanding spacer recruitment from foreign DNA, production of small RNAs, in vitro activity of CRISPR-associated protein complexes and attack of viruses and plasmids in in vivo test systems are addressed.
Characterisation of proteins involved in CRISPR-mediated antiviral defence in Sulfolobus solfataricus
TLDR
The biochemical characteristics of CRISPR-mediated defense in the crenarchaeon Sulfolobus solfataricus is described, and the recognition and silencing of DNA targets in E. coli has been shown to involve a multiprotein complex termed CASCADE as well as Cas3, a putative helicase-HD nuclease.
Characterization of the CRISPR/Cas Subtype I-A System of the Hyperthermophilic Crenarchaeon Thermoproteus tenax
TLDR
Seven CRISPR loci in the genome of the crenarchaeon Thermoproteus tenax that include spacers with significant similarity not only to archaeal viruses but also to T. tenax genes are investigated to provide insights into the specialized mechanisms of an archaealing CRISpr/Cas system and allow selective functional analyses of Cas protein complexes in the future.
Crystal structure of Cas1 from Archaeoglobus fulgidus and characterization of its nucleolytic activity.
CRISPR/Cas system and its role in phage-bacteria interactions.
TLDR
Recent progress made in the CRISPR/Cas system is described, which participates in a constant evolutionary battle between phages and bacteria through addition or deletion of spacers in host cells and mutations or deletion in phage genomes.
Characterisation of the CRISPR/Cas system of the hyperthermophilic Archaeum Thermoproteus tenax
TLDR
The function of the archaeal CRISPR/Cas system is studied in more detail using the hyperthermophilic organism Thermoproteus tenax as an example and sevenCRISPR loci could be identified in the genome of T. tenax.
In vivo activity of CRISPR‐mediated virus defence in a hyperthermophilic archaeon
TLDR
In vivo activity of CRISPR/Cas in archaea for the first time is demonstrated and it is suggested that – unlike the recently demonstrated in vitro cleavage of RNA in Pyrococcus– DNA is targeted in this archaeon.
Double-stranded Endonuclease Activity in Bacillus halodurans Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated Cas2 Protein*
TLDR
This work shows that the Bacillus halodurans Cas2 (Bha_Cas2) from the subtype I-C/Dvulg CRISPR instead possesses metal-dependent endonuclease activity against double-stranded (ds)DNA, and proposes that the distinct substrate preferences among Cas2 proteins may be determined by the sequence and structure in the β1–α1 loop.
The CRISPR-Associated Gene cas2 of Legionella pneumophila Is Required for Intracellular Infection of Amoebae
TLDR
Analysis of the Legionella pneumophila strain 130b chromosome detected a subtype II-B CRISPR-Cas locus that contains cas9, cas1, cas2, cas4, and an array with 60 repeats and 58 unique spacers that indicates that cas2 has a role in the transmission of Legionnaires' disease.
Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems
TLDR
Evidence is presented that large subunits contained in most of the CRISPR-Cas systems could be homologous to Cas10 proteins which contain a polymerase-like Palm domain and are predicted to be enzymatically active in Type III CRISpr-cas systems but inactivated in Type I systems.
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References

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A mechanism by which this HGT has occurred is suggested, namely, that the CRISPR loci can be carried between cells on megaplasmids ≥40 kb in length.
Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes.
TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
A novel family of repetitive DNA sequences that is present among both domains of the prokaryotes but absent from eukaryotes or viruses is studied, characterized by direct repeats, varying in size from 21 to 37 bp, interspaced by similarly sized non‐repetitive sequences.
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