• Corpus ID: 41619869

SSC 14-VII-3 BioSentinel : Monitoring DNA Damage Repair Beyond Low Earth Orbit on a 6 U Nanosatellite

@inproceedings{Lewis2014SSC1B,
  title={SSC 14-VII-3 BioSentinel : Monitoring DNA Damage Repair Beyond Low Earth Orbit on a 6 U Nanosatellite},
  author={Brian Lewis and Robert P. Hanel and Sharmila Bhattacharya and Antonio J. Ricco and Elwood F. Agasid and Debra Reiss-Bubenheim and Tore Straume and Macarena P Parra and Travis David Boone and Sergio R. Santa Maria and Ming X. Tan and Robert N. Bowman and Matt Sorgenfrei and Matthew Nehrenz and Marina Gandlin and Terry C. Lusby and Vanessa Kuroda and Craig Pires and Abraham Rademacher and Joshua and Benton and Shang-Hsin Wu and Benjamin A. Klamm and Charlie Friedericks and Colleen Hake and Edward J. Semones and Scott Wheeler and Susan Gavalas and Sarah L. Castro},
  year={2014}
}
We are designing and developing a “6U” nanosatellite as a secondary payload to fly aboard NASA’s Space Launch System (SLS) Exploration Mission (EM) 1, scheduled for launch in late 2017. For the first time in over forty years, direct experimental data from biological studies beyond low Earth orbit (LEO) will be obtained during BioSentinel’s 12 to 18-month mission. BioSentinel will measure the damage and repair of DNA in a biological organism and compare that to information from onboard physical… 

References

SHOWING 1-10 OF 11 REFERENCES
Induction and Repair of DNA Double-Strand Breaks under Irradiation and Microgravity
TLDR
The results show that there is no significant difference for both the induction and the repair of double-strand breaks between microgravity and terrestrial conditions.
Spectrum of Complex DNA Damages Depends on the Incident Radiation
TLDR
The yields (damages/Mbp Gy−1) of all damages decreased with increasing linear energy transfer (LET) of the radiation, and the relative frequencies of DSBs compared to abasic and oxybase clusters were higher for the charged particles—including the high-energy, low-LET protons—than for the ionizing photons.
Heavy Ion-Induced DNA Double-Strand Breaks in Yeast
TLDR
Comparison of the derived breakage cross sections with the corresponding cross section for inactivation derived from the terminal slope of the survival curves shows a strong linear relationship between these cross sections, extending over several orders of magnitude.
Rad9, an evolutionarily conserved gene with multiple functions for preserving genomic Integrity
TLDR
Analysis of the functions of Rad9 should not only provide information about the molecular mechanisms of several individual cellular processes, but might also lend insight into the more global control and coordination of what at least superficially present as independent pathways.
Recombination proteins in yeast.
TLDR
Recently studies showing defects in homologous recombination and double-strand break repair in several human cancer-prone syndromes have emphasized the importance of this repair pathway in maintaining genome integrity.
FITPix ? fast interface for Timepix pixel detectors
TLDR
A new readout interface for silicon pixel detectors of the Medipix family has been developed in this group in order to provide a higher frame rate and enhanced flexibility of operation.
Small Class-D spacecraft thermal design, test and analysis - PharmaSat biological experiment
Small spacecraft have been increasing in popularity because of their low cost, short turnaround and relative efficiency. In the past, small spacecraft have been primarily used for technology
An Enhanced Role for Scientific CubeSats at NASA,
  • Annual CubeSat Developers’ Workshop,
  • 2014
...
1
2
...