SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production.


SS-A/Ro52 (Ro52), an autoantigen in systemic autoimmune diseases such as systemic lupus erythematosus and Sjögren's syndrome, has E3 ligase activity to ubiquitinate proteins that protect against viral infection. To investigate Ro52's role during stress, we transiently knocked it down in HeLa cells by siRo52 transfection. We found that Ro52(low) HeLa cells… (More)
DOI: 10.1016/j.bbrc.2011.12.010

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@article{Jauharoh2012SSARo52PA, title={SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production.}, author={Siti Nur Aisyah Jauharoh and Jun Saegusa and Takeshi Sugimoto and Bambang Ardianto and Shimpei Kasagi and Daisuke Sugiyama and Chiyo Kurimoto and Osamu Tokuno and Yuji Nakamachi and S. Kumagai and Seiji Kawano}, journal={Biochemical and biophysical research communications}, year={2012}, volume={417 1}, pages={582-7} }