SRY protein function in sex determination: thinking outside the box

  title={SRY protein function in sex determination: thinking outside the box},
  author={Liang Zhao and Peter Koopman},
  journal={Chromosome Research},
Even though the mammalian sex-determining gene Sry has been intensively studied for the two decades since its discovery, the regions outside the conserved HMG box DNA-binding domain have received less attention due to a lack of sequence conservation and of obvious structural/functional motifs. Here, we summarize the available evidence for function beyond the HMG box, identify the known and postulated biochemical functions of the non-HMG-box domains in sex determination, and present possible… CONTINUE READING

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