SRY: A transcriptional activator of mammalian testis determination.

  title={SRY: A transcriptional activator of mammalian testis determination.},
  author={Ryohei Sekido},
  journal={The international journal of biochemistry & cell biology},
  volume={42 3},
Sry (sex-determining region Y) is the sex-determining gene on the mammalian Y chromosome, which encodes a transcription factor containing a DNA-binding domain characteristic of some high mobility group proteins (HMG box). It is the founder member of the Sox (Sry-related HMG box) gene family and is therefore classified in the Sox A group. In mice, the transient expression of Sry between 10.5 and 12.5 dpc triggers the differentiation of Sertoli cells from the supporting cell precursor lineage… CONTINUE READING
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