SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.

@article{Suzuki2012SRT1720AS,
  title={SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.},
  author={Kensuke Suzuki and Ryuji Hayashi and Tomomi Ichikawa and Shingo Imanishi and Toru Yamada and Minehiko Inomata and Toshiro Miwa and Shoko Matsui and Isao Usui and Masaharu Urakaze and Yuji Matsuya and Hirofumi Ogawa and Hiroaki Sakurai and Ikuo Saiki and Kazuyuki Tobe},
  journal={Oncology reports},
  year={2012},
  volume={27 6},
  pages={1726-32}
}
Silent information regulator 2 (SIR2) is a highly conserved protein, the mammalian orthologue of which, SIRT1, exhibits histone deacetylase activity. SIRT1 is involved not in only longevity due to caloric restriction but in a variety of diseases such as diabetes, cardiovascular dysfunction and neurodegeneration. However, accumulating evidence shows that SIRT1 is overexpressed in various types of malignant cells, and its inhibitors… CONTINUE READING