SRSF2 promotes splicing and transcription of exon 11 included isoform in Ron proto-oncogene.

@article{Moon2014SRSF2PS,
  title={SRSF2 promotes splicing and transcription of exon 11 included isoform in Ron proto-oncogene.},
  author={Heegyum Moon and Sunghee Cho and Tiing Jen Loh and Hyun Kyung Oh and Ha Na Jang and Jian-hua Zhou and Young-Soo Kwon and D. Joshua Liao and Youngsoo Jun and Soo Hyun Eom and Claudia Ghigna and Giuseppe Biamonti and Michael R. Green and Xuexiu Zheng and Haihong Shen},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1839 11},
  pages={
          1132-40
        }
}
The product of proto-oncogene Ron is a human receptor for the macrophage-stimulating protein (MSP). Upon activation, Ron is able to induce cell dissociation, migration and matrix invasion. Exon 11 skipping of Ron pre-mRNA produces Ron△165 protein that is constitutively active even in the absence of its ligand. Here we show that knockdown of SRSF2 promotes the decrease of exon 11 inclusion, whereas overexpression of SRSF2 promotes exon 11 inclusion. We demonstrate that SRSF2 promotes exon 11… CONTINUE READING
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