SRSF2 mutations in primary myelofibrosis: significant clustering with IDH mutations and independent association with inferior overall and leukemia-free survival.

@article{Lasho2012SRSF2MI,
  title={SRSF2 mutations in primary myelofibrosis: significant clustering with IDH mutations and independent association with inferior overall and leukemia-free survival.},
  author={Terra L. Lasho and Thitina Jimma and Christy M. Finke and Mrinal S Patnaik and Curtis A. Hanson and Rhett P. Ketterling and Animesh Pardanani and Ayalew Tefferi},
  journal={Blood},
  year={2012},
  volume={120 20},
  pages={4168-71}
}
Among spliceosome component mutations, those involving SF3B1 are most frequent in myelodysplastic syndromes with ring sideroblasts (MDS-RS; ∼ 75% incidence) and SRSF2 in chronic myelomonocytic leukemia (∼ 28% incidence). We recently reported on the lack of prognostic significance for SF3B1 mutations in both MDS-RS and primary myelofibrosis (PMF). In the current study, we examined the prevalence and prognostic relevance of SRSF2 mutations in PMF. Among 187 patients screened, 32 (17%) harbored… CONTINUE READING
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