SRRM2, a Potential Blood Biomarker Revealing High Alternative Splicing in Parkinson's Disease

  title={SRRM2, a Potential Blood Biomarker Revealing High Alternative Splicing in Parkinson's Disease},
  author={Lina A. Shehadeh and Kristine Yu and Liyong Wang and Alexandra Guevara and Carlos Singer and Jeffery Vance and Spyridon Papapetropoulos},
  booktitle={PloS one},
BACKGROUND Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects about five million people worldwide. Diagnosis remains clinical, based on phenotypic patterns. The discovery of laboratory markers that will enhance diagnostic accuracy, allow pre-clinical detection and tracking of disease progression is critically needed. These biomarkers may include transcripts with different isoforms. METHODOLOGY/PRINCIPAL FINDINGS We performed extensive analysis on 3 PD microarray… CONTINUE READING


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