SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases.

Abstract

SRPK1 (serine-arginine protein kinase 1) is a protein kinase that specifically phosphorylates proteins containing serine-arginine-rich domains. Its substrates include a family of SR proteins that are key regulators of mRNA AS (alternative splicing). VEGF (vascular endothelial growth factor), a principal angiogenesis factor contains an alternative 3' splice… (More)
DOI: 10.1042/BST20120051

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