SRI-286, a Thiosemicarbazole, in Combination with Mefloquine and Moxifloxacin for Treatment of Murine Mycobacterium avium Complex Disease

@article{Bermudez2004SRI286AT,
  title={SRI-286, a Thiosemicarbazole, in Combination with Mefloquine and Moxifloxacin for Treatment of Murine Mycobacterium avium Complex Disease},
  author={L. Bermudez and P. Kolonoski and L. E. Seitz and M. Petrofsky and Robert Reynolds and M. Wu and L. S. Young},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2004},
  volume={48},
  pages={3556 - 3558}
}
  • L. Bermudez, P. Kolonoski, +4 authors L. S. Young
  • Published 2004
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • ABSTRACT Treatment of Mycobacterium avium disease remains challenging when macrolide resistance develops. We infected C57 beige mice and treated them with mefloquine, SRI-286, and moxifloxacin. SRI-286 (80 mg/kg) was bactericidal in the liver. Mefloquine plus moxifloxacin or mefloquine plus SRI-286 were better than mefloquine alone. 
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