SRI-286, a Thiosemicarbazole, in Combination with Mefloquine and Moxifloxacin for Treatment of Murine Mycobacterium avium Complex Disease

  title={SRI-286, a Thiosemicarbazole, in Combination with Mefloquine and Moxifloxacin for Treatment of Murine Mycobacterium avium Complex Disease},
  author={Luiz E. Bermudez and Peter Kolonoski and L E Seitz and Mary Petrofsky and Robert C. Reynolds and Martin Wu and Lowell S. Young},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={3556 - 3558}
ABSTRACT Treatment of Mycobacterium avium disease remains challenging when macrolide resistance develops. We infected C57 beige mice and treated them with mefloquine, SRI-286, and moxifloxacin. SRI-286 (80 mg/kg) was bactericidal in the liver. Mefloquine plus moxifloxacin or mefloquine plus SRI-286 were better than mefloquine alone. 

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