SRF selectively controls tip cell invasive behavior in angiogenesis.

  title={SRF selectively controls tip cell invasive behavior in angiogenesis.},
  author={Claudio A. Franco and Jocelyne Blanc and Ara Parlakian and Raquel Justo Blanco and Irene Maria Aspalter and Natalia Kazakova and Nicolas Diguet and Elena Mylonas and Jacqueline Gao-Li and Anne Vaahtokari and Virgine Penard-Lacronique and Markus Fruttiger and Ian R. Rosewell and Mathias Mericskay and Holger Gerhardt and Zhenlin Li},
  volume={140 11},
Efficient angiogenic sprouting is essential for embryonic, postnatal and tumor development. Serum response factor (SRF) is known to be important for embryonic vascular development. Here, we studied the effect of inducible endothelial-specific deletion of Srf in postnatal and adult mice. We find that endothelial SRF activity is vital for postnatal growth and survival, and is equally required for developmental and pathological angiogenesis, including during tumor growth. Our results demonstrate… CONTINUE READING
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