SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development.

@article{Schratt2004SRFRB,
  title={SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development.},
  author={Gerhard Schratt and Ulrike Philippar and Dirk Hockemeyer and Heinz J. Schwarz and Siegfried Alberti and A. Nordheim},
  journal={The EMBO journal},
  year={2004},
  volume={23 8},
  pages={1834-44}
}
The transcription factor serum response factor (SRF) controls the expression of genes involved in cellular proliferation and differentiation. Interestingly, SRF also promotes cell survival by regulating the expression of antiapoptotic genes. In in vitro differentiating murine embryonic stem (ES) cells, SRF deficiency leads to increased apoptosis. Loss of SRF correlates with impaired expression of the antiapoptotic Bcl-2 and Bcl-xl genes. SRF binds the Bcl-2 promoter in vivo and activates Bcl-2… CONTINUE READING

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