SREBPs: the crossroads of physiological and pathological lipid homeostasis.

  title={SREBPs: the crossroads of physiological and pathological lipid homeostasis.},
  author={Rajendra Raghow and Chandrahasa R Yellaturu and Xiong Deng and Edwards A. Park and Marshall B Elam},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={19 2},
The uptake, biosynthesis and metabolism of cholesterol and other lipids are exquisitely regulated by feedback and feed-forward pathways in organisms ranging from Caenorhabditis elegans to humans. As endoplasmic reticulum (ER) membrane-embedded transcription factors that are activated in the Golgi apparatus, sterol regulatory element-binding proteins (SREBPs) are central to the intracellular surveillance of lipid catabolism and de novo biogenesis. The biosynthesis of SREBP proteins, their… CONTINUE READING