SREBPs: sterol-regulated transcription factors.

  title={SREBPs: sterol-regulated transcription factors.},
  author={Peter J. Espenshade},
  journal={Journal of cell science},
  volume={119 Pt 6},
Studies of the feedback regulation of cholesterol synthesis in animals have led to the identification of a unique family of membrane-bound transcription factors, sterol regulatory element binding proteins (SREBPs) (Brown and Goldstein, 1997). In the presence of cholesterol, SREBPs are sequestered in the endoplasmic reticulum (ER). In the absence of a sterol signal, however, SREBPs undergo specific proteolytic events that lead to activation of distinct sets of target genes that control lipid… CONTINUE READING

From This Paper

Topics from this paper.
59 Citations
43 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 59 extracted citations


Publications referenced by this paper.
Showing 1-10 of 43 references

Similar Papers

Loading similar papers…