SREBPs: metabolic integrators in physiology and metabolism.

@article{Jeon2012SREBPsMI,
  title={SREBPs: metabolic integrators in physiology and metabolism.},
  author={Tae-Il Jeon and Timothy F. Osborne},
  journal={Trends in endocrinology and metabolism: TEM},
  year={2012},
  volume={23 2},
  pages={65-72}
}
Recent advances have significantly increased our understanding of how sterol regulatory element binding proteins (SREBPs) are regulated at the transcriptional and post-transcriptional levels in response to cellular signaling. The phosphatidyl inositol-3-kinase (PI3K) and SREBP pathways intersect at multiple points, and recent insights demonstrate the importance of tight regulation of the PI3K pathway for regulating SREBPs in the adaptation to fluctuating dietary calorie load in the mammalian… CONTINUE READING
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