SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein.

@article{Oliner1996SREBPTA,
  title={SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein.},
  author={Jonathan Daniel Oliner and Jennifer M. Andresen and Solveig Kallesoe Hansen and Sifang Zhou and Robert Tjian},
  journal={Genes & development},
  year={1996},
  volume={10 22},
  pages={
          2903-11
        }
}
The sterol regulatory element binding proteins (SREBP-1 and -2) activate transcription of genes whose products are involved in the cellular uptake and synthesis of cholesterol. Although considerable effort has been exerted to define the events regulating the levels of active SREBP, little is known about the transcriptional cofactors mediating SREBP function. In an unbiased search for potential coactivators of SREBP, we isolated a protein of 265 kD from HeLa cells that directly bound SREBP-1 and… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Interaction of the coactivator CBP with Myb proteins : Effects on Myb - specific transactivation and on the cooperativity with NF - M

  • K. W. Kinzler, P. S. Meltzer, D. L. George, B. Vogelstein
  • EMBO J
  • 1996

Nucle - olar transcription factor hUBF contains a DNA - binding motif with homology to HMG proteins

  • L. Xu, T. Heinzel, +7 authors M. G. Rosenfeld
  • Nature
  • 1996

quence and characterization of a coactivator for the steroid hormone receptor superfamily

  • E. A. Duncan, R. B. Rawson, X. Hua, M. S. Brown, J. L. Goldstein
  • Science
  • 1995

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