SREBP in signal transduction: cholesterol metabolism and beyond.

  title={SREBP in signal transduction: cholesterol metabolism and beyond.},
  author={Maria Teresa Bengoechea-Alonso and Johan Ericsson},
  journal={Current opinion in cell biology},
  volume={19 2},
The last few years have seen important advances in defining the mechanisms that cells use to monitor changes in cholesterol levels and regulate lipid metabolism. This work has unraveled a feedback system that enables cholesterol and certain sterol intermediates to regulate the proteolysis and transport of specific membrane proteins. The sterol regulatory element-binding protein (SREBP) family of transcription factors is at the center of this feedback system. These membrane-embedded proteins are… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.
95 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 95 extracted citations

Similar Papers

Loading similar papers…