SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats.

@article{Aragno2009SREBP1cIN,
  title={SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats.},
  author={Manuela Aragno and Chiara Elena Tomasinelli and Ilenia Vercellinatto and Maria Graziella Catalano and Massimo Collino and Roberto Fantozzi and Oliviero Danni and Giuseppe Boccuzzi},
  journal={Free radical biology & medicine},
  year={2009},
  volume={47 7},
  pages={1067-74}
}
This study concentrated on the initial events triggering the development of nonalcoholic fatty liver disease induced by a high-fat plus fructose (HF-F) diet and on the possibility of delaying nonalcoholic fatty liver disease progression by adding dehydroepiandrosterone (DHEA) to the diet. Sterol regulatory element binding protein-1c (SREBP-1c) activation plays a crucial role in the progression of nonalcoholic fatty liver disease induced by an HF-F diet. This study investigated the protective… CONTINUE READING