SREBP-1: gene regulatory key to syndrome X?

  title={SREBP-1: gene regulatory key to syndrome X?},
  author={Dirk M{\"u}ller-Wieland and J{\"o}rg Kotzka},
  journal={Annals of the New York Academy of Sciences},
Combined appearance of different cardiovascular risk factors seems to be more prevalent in individuals with decreased insulin sensitivity and increased visceral obesity, thereby being components of the so-called metabolic syndrome or syndrome X. Alterations in the abundance and activity of transcription factors lead to complex dysregulation of gene expression, which might be a key to understand insulin resistance-associated clinical clustering of coronary risk factors at the cellular or gene… CONTINUE READING


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