SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

@article{Wang1994SREBP1AM,
  title={SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis},
  author={X. Wang and R. Sato and M. Brown and X. Hua and J. Goldstein},
  journal={Cell},
  year={1994},
  volume={77},
  pages={53-62}
}
  • X. Wang, R. Sato, +2 authors J. Goldstein
  • Published 1994
  • Biology, Medicine
  • Cell
  • Sterol regulatory element-binding protein 1 (SREBP-1), a member of the basic-helix-loop-helix-leucine zipper (bHLH-ZIP) family of transcription factors, is synthesized as a 125 kd precursor that is attached to the nuclear envelope and endoplasmic reticulum. In sterol-depleted cells, the membrane-bound precursor is cleaved to generate a soluble NH2-terminal fragment (apparent molecular mass, 68 kd) that translocates to the nucleus. This fragment, which includes the bHLH-ZIP domain, activates… CONTINUE READING
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