SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

@article{Yokoyama1993SREBP1AB,
  title={SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene},
  author={C. Yokoyama and X. Wang and M. R. Briggs and A. Admon and M. Brown},
  journal={Cell},
  year={1993},
  volume={75},
  pages={187-197}
}
  • C. Yokoyama, X. Wang, +2 authors M. Brown
  • Published 1993
  • Biology, Medicine
  • Cell
  • Sterol regulatory element 1 (SRE-1), a decamer (5'-ATC-ACCCCAC-3') flanking the low density lipoprotein (LDL) receptor gene, activates transcription in sterol-depleted cells and is silenced by sterols. We report the cDNA cloning of human SREBP-1, a protein that binds SRE-1, activates transcription, and thereby mediates the final regulatory step in LDL metabolism. SREBP-1 contains a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) motif, but it differs from other bHLH-ZIP proteins in its larger… CONTINUE READING
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