SRC regulates constitutive internalization and rapid resensitization of a cholecystokinin 2 receptor splice variant.

@article{Chao2005SRCRC,
  title={SRC regulates constitutive internalization and rapid resensitization of a cholecystokinin 2 receptor splice variant.},
  author={Celia Chao and Kirk L Ives and Elizabeth Goluszko and Andrey A. Kolokoltsov and Robert A Davey and Courtney M. Townsend and Mark R. Hellmich},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 39},
  pages={33368-73}
}
The third intracellular loop domain of G protein-coupled receptors regulates their desensitization, internalization, and resensitization. Colorectal and pancreatic cancers, but not the nonmalignant tissue, express a splice variant of the cholecystokinin 2 receptor (CCK2R) called CCK(2i4sv)R that, because of intron 4 retention, contains an additional 69 amino acids within its third intracellular loop domain. This structural alteration is associated with agonist-independent activation of Src… CONTINUE READING

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